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English: During transcription initiation, proteins (dark grey semi-circles) bound to distant regions of the DNA can be brought into proximity with each other since the intervening DNA can loop back on itself. The basal transcription machinery can interact with distant activators and repressors many kilobases upstream or downstream of the open reading frame.
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Pakay, Julian (2023) Threshold Concepts in Biochemistry, La Trobe eBureau DOI: 10.26826/1017. ISBN: 978-0-6484681-9-6.

Adapted from File:Gene structure eukaryote 2 annotated.svg
Aata Thomas Shafee
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